Collège Doctoral - Doktorandenkollegien

Statistical Physics of Complex Systems

Coventry - Leipzig - Lviv - Nancy

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Publication

Title Identification of Characteristic Protein Folding Channels in a Coarse-Grained Hydrophobic-Polar Peptide Model
Authors S. Schnabel, M. Bachmann, and W. Janke
Reference J. Chem. Phys. 126 (2007) 105102(1-6)
DOI10.1063/1.2437204
Abstract Folding channels and free-energy landscapes of hydrophobic-polar heteropolymers are discussed on the basis of a minimalistic off-lattice coarse-grained model. We investigate how rearrangements of hydrophobic and polar monomers in a heteropolymer sequence lead to completely different folding behaviors. Studying three exemplified sequences with the same content of hydrophobic and polar residues, we can reproduce within this simple model two-state folding, folding through intermediates, as well as metastability.


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